Conferencia científica internacional que cubre todos los aspectos relacionados con la comunicación celular medida por conexinas, ponexinas e inexinas. El programa de estas conferencias cubre un amplio rango de temas de vanguardia que van desde la bioquímica estructural a la biología celular, la fisiología molecular hasta ensayos clínicos. La mayoría de los asistentes son científicos extranjeros provenientes de cinco continentes.
Comité Organizador invita a científicos, postdoctorales y estudiantes de todo el mundo para asistir y participar activamente en la Conferencia 2015 Internacional Gap Junction en Valparaíso, Chile. Esta conferencia es una excelente oportunidad para interactuar y discutir varios aspectos del campo con científicos de todo el mundo.
Esta conferencia internacional es organizada por el Centro Interdisciplinario de Neurociencia de la Universidad de Valparaíso.
Program Sunday March 29th, 2015
9:00-10:00 Keynote talk 1
Tomás Pérez-Acle: “Structure-function relationships coded at the molecular architecture of Cx26 hemichannels”
10:00-11:00 Platform session 1
Structural and biophysical aspects of hemichannels and gap junction channels (I)
Chair: Donglin Bai and Jorge E. Contreras
1) The first transmembrane segment of connexins and voltage-dependent gating regulation of hemichannels. Bernardo Pinto-Chile.
2) Effect of pH and phosphorylation on the secondary structure of the CT domain from different connexin isoforms. Paul Sorgen-USA.
3) GJCs make-up in function of accurate ratios of Cx40/Cx43 and Cx43/Cx45. Thomas Desplantez-France.
4) Cx43 channel gating: evaluating triggers and mechanisms. Jose Ek-Vitorin-USA.
11:00-11:30 Coffee break
11:30-12:30 Platform session 2
Structural and biophysical aspects of hemichannels and gap junction channels (II)
Chair: Janis M. Burt and Virginijus Valiunas
5) Motifs in the permeation pathways of connexin channels that mediate Ca2+ sensing. Jorge E. Contreras-USA.
6) Engineered Cx40 variants showed heterotypic colocalization and increased gap junctional coupling with Cx43. Donglin Bai-Canada.
7) Differential properties of N14K and N14Y KID mutant hemichannels: structure-function implications. Vytautas Verselis-USA.
8) The SH3-binding domain controls the activity of Cx43 hemichannels. Jegan Iyyathurai-Belgium.
12:30-14:00 Lunch at Parque Cultural de Valparaíso (PCDV)
14:00-15:00 Keynote talk 2
Alberto Pereda: “Properties and plasticity of synaptic transmission mediated by gap junctions in the vertebrate brain”
15:00-16:00 Platform session 3
Principles and cell biology of electrical synapses
Chair: Vytautas K. Verselis and Thomas Desplantez
9) Electrical synapses: First principles last or some things never change. Michael V.L. Bennett-USA.
10) Modulation of the IH current enhances coincidence detection between electrically coupled neurons of the mesencephalic trigeminal (MesV) nucleus of the rat. Sebastian Curti-Uruguay.
11) Mechanisms underlying plasticity of electrical synapses in the thalamic reticular nucleus. Julie Haas-USA.
12) Calcium signaling at Cx36 gap junctions in cultured cells and retinal neurons. John O’Brien-USA.
16:00-16:30 Coffee break
16:30-17:30 Platform session 4
Pannexin channels in the nervous system
Chair: Roger J. Thompson and Julie S. Haas
13) A non-canonical signaling modality for NMDA receptors and Pannexin 1 in ischemia. Nicholas Weilinger-Canada.
14) Pannexin 1 sets the threshold of excitatory synaptic plasticity in the hippocampus from adult mice. Alvaro Ardiles-Chile.
15) A novel interaction between Pannexin 1 and Collapsin Response Mediator Protein 2 regulates neuronal development. Leigh Wicki-Stordeur-Canada.
16) Pannexin 1 activation is required to NMDAR and P2X7R signaling of the nociceptive information in the spinal cord of neuropathic rats. David Bravo-Chile.
17:30-19:30 Poster session I
19:30 Please find your preferred dinner at Valparaiso´s restaurants. Information about restaurants will be available at the meeting.
