Conferencia científica internacional que cubre todos los aspectos relacionados con la comunicación celular medida por conexinas, ponexinas e inexinas. El programa de estas conferencias cubre un amplio rango de temas de vanguardia que van desde la bioquímica estructural a la biología celular, la fisiología molecular hasta ensayos clínicos. La mayoría de los asistentes son científicos extranjeros provenientes de cinco continentes.
Comité Organizador invita a científicos, postdoctorales y estudiantes de todo el mundo para asistir y participar activamente en la Conferencia 2015 Internacional Gap Junction en Valparaíso, Chile. Esta conferencia es una excelente oportunidad para interactuar y discutir varios aspectos del campo con científicos de todo el mundo.
Esta conferencia internacional es organizada por el Centro Interdisciplinario de Neurociencia de la Universidad de Valparaíso.
Program Monday March 30th, 2015
9:00-10:00 Keynote talk 3
Eduardo Macagno: “Roles of Innexins in Nervous System Development”
10:00-11:00 Platform session 5
Innexin, connexin and pannexin based-channels
Chair: Michael V.L. Bennett and John O’Brien
17) A different role for Innexin2 and Innexin3 proteins from Spodoptera litura in apoptosis under hemichannel-closed Sf9 cells infected by recombinant baculoviruses. Kaijun Luo-China.
18) Comparing innexin- and connexin-based channels using structure-function analysis. Martha Skerrett-USA.
19) ATP-evoked internalization of Pannexin 1 channels. Andrew Boyce-Canada.
20) Lack of Pannexin 1 alters permeability of cochlear supporting cells and induces sensorineural hearing loss. Pavel Prado-Chile.
11:00-11:30 Coffee break
11:30-12:30 Platform session 6
Pannexin based-channels
Chair: Jean X. Jiang and Anaclet Ngezahayo
21) Human development disorders linked to a germ-line missense PANX1 gene mutation. Dale Laird-Canada.
22) Pannexin 1 in smooth muscle cells of cerebral arteries can alter cerebral blood flow and response to ischemic stroke via regulation of myogenic tone. Miranda Good-USA.
23) Pannexin 1 in the response of developing neurons to stroke. Leigh Anne Swayne-Canada
24) α1-adrenergic receptor activation phosphorylates Pannexin 1 at tyrosine 198 via src family kinases. Leon DeLalio-USA.
12:30-14:00 Lunch at Centro cultural de Valparaíso (PCDV)
14:00-15:00 Platform session 7
Regulation and traffic of hemichannels and gap junction channels (I)
Chair: Matthias Falk and Mathieu Vinken
25) Prevention of Cx37 de-phosphorylation at tyrosine 332 is pivotal for the inhibitory NO effect on GJC. Petra Kameritsch-Germany.
26) Control of astrocyte calcium signaling through NO-dependent regulation of hemichannel opening. Mariela Puebla-Chile.
27) Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ and are a potential arrhythmogenic substrate in the heart. Luc Leybaert-Belgium.
28) Ca2+/calmodulin regulation of connexin. Jenny Yang-USA.
15:00-15:30 Coffee break
15:30-16:30 Platform session 8
Cell-cell communication channels in organ systems (II)
Chair: Sandra A. Murray and Jonathan M. Gibbins
29) Regulation of gap junction channels and hemichannels by actin cytoskeleton and RhoA. Oscar Jara-Chile.
30) Hierarchical phosphorylation events in the Connexin 43 tail-domain signal gap junction internalization. Matthias Falk-USA.
31) Cx43 augments filopodia formation via activation of p21-activated protein kinase 1 (PAK1). Kristin Pogoda-Germany.
32) Signals and mechanisms regulating endocytosis across the connexin protein family. Charles Fisher-USA.
16:30- 18:30 Poster session II
18:30 Please find your preferred dinner at Valparaiso´s restaurants. Information about restaurants will be available at the meeting.
